Tagged: hybridoma sequencing
1. “The variable regions of the heavy and light chains of the MAbs were sequenced at the DNA level (Syd Labs, Malden, MA).” Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus. Martinez-Navio JM, Desrosiers RC. 2012 J Virol. 86(23): 12484-93.
2. “The 2H2 108 antibody amino acid sequences of the light and heavy chain variable domains were determined by Syd Labs, Inc.” Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody. Wang Z, Li L, Pennington JG, Sheng J, Yap ML, Plevka P, Meng G, Sun L, Jiang W, Rossmann MG. 2013 J Virol. 87(16):8909-15.
3. “the heavy and light chains of MAbs A6.1 and A6.2 were sequenced by Syd Labs, Inc. (Boston, MA), and found to be identical.” Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization. Kolawole AO, Li M, Xia C, Fischer AE, Giacobbi NS, Rippinger CM, Proescher JB, Wu SK, Bessling SL, Gamez M, Yu C, Zhang R, Mehoke TS, Pipas JM, Wolfe JT, Lin JS, Feldman AB, Smith TJ, Wobus CE. 2014 J Virol. 88(8):4543-57.
Syd Labs, Inc can complete a hybridoma sequencing project as short as 4 days.
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